Security practice vs. risk management practice
The CISSP is designed for security practitioners across the full security lifecycle — engineers, architects, operations leads, managers, and CISOs whose primary job is designing, operating, and governing security.
The CRISC is designed specifically for IT risk professionals. Its four domains — governance, IT risk assessment, risk response and reporting, and information technology and security — center on identifying enterprise IT risk, evaluating it, designing controls, and reporting on residual risk to leadership. The CRISC holder's job is not to operate security; it is to understand and manage the risk that security exists to mitigate.